WebFeb 14, 2024 · The transcription factor FoxO3A is a key determinant of cancer cell homeostasis, playing a dual role in survival/death response to metabolic stress and cancer therapeutics. We recently described a novel mitochondrial arm of the AMPK-FoxO3A axis in normal cells upon nutrient shortage. WebDec 1, 2016 · For example, FoxO3a activates FasL transcription, the ligand for the Fas-dependent cell death pathway or pro-apoptotic Bim gene and initiates apoptosis. FoxO3a also induces the expression of cell cycle progression inhibitors including p27 and CyclinD1, thus stalling the G1/S phase transition . Here, we investigated whether the survival …
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WebIOP1抗体、Lamin A/C抗体、LC3BⅠ抗体、LC3BⅡ抗体、FOXO3a抗体、p62抗体、ATG5、ATG12抗体、GAPDH抗体均购自美国CST公司。荧光定量PCR仪型号为LightCycler 480，购自瑞士罗氏公司。 1.2方法. 1.2.1细胞培养 HEK293T在37 ℃，5% CO2培养箱中用含10% FBS的高糖DMEM培养基培养。 WebJun 28, 2024 · The following primary antibodies were used: Ubiquitin (#3933; Cell Signaling Technology (CST) Japan, Tokyo, Japan), p-Forkhead box O (FOXO) 1 Ser256 (#84192; CST), FOXO1 (#2880; CST), p-FOXO3a Ser253 (#9466; CST), FOXO3a (#2497; CST), LC3 (#2775; CST), p62/SQSTM (PM045, Medical & Biological Laboratory, Nagoya, Japan), p …
WebMonoclonal Antibody for studying FoxO3a. Cited in 187 publications. Validated for WB, IP, IHC, IF, F. Highly specific and rigorously validated in-house, FoxO3a (D19A7) Rabbit Monoclonal Antibody (CST #12829) is … WebFOXO3a were positively correlated, and both were associated with longer sur-vival in lung cancer patients. Conclusion: Overall, the present study is the first to show that Adjudin syner-gizes with paclitaxel and inhibits cell growth and metastasis by regulating the SIRT3–FOXO3a axis in SCLC; thus, Adjudin has great potential to be an anti-
WebMonoclonal Antibody for studying FoxO3a. Cited in 455 publications. Validated for WB, IP, IF. Highly specific and rigorously validated in … WebThe FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA …
WebFOXO3a is a transcription factor of the FOXO family. The FOXO proteins participate in multiple signaling pathways, and their transcriptional activity is regulated by several post …
Web豆丁网是面向全球的中文社会化阅读分享平台，拥有商业,教育,研究报告,行业资料,学术论文,认证考试,星座,心理学等数亿实用 ... did challenger crew surviveWebJan 1, 2012 · Doxorubicn treatment induces p38 MAPK activity and FOXO3a nuclear accumulation in MCF-7 breast carcinoma cell line. A, MCF-7 cells were treated with 1 μmol/liter of doxorubicin for 0, 1, 2, 4, 8, 16, and 24 h. At the indicated time, the cells were collected and analyzed by Western blotting using the antibodies indicated. city life church live streamWeb(12829) FoxO3a (D19A7) Rabbit mAb Sign in or register to save this reagent to your favourites Supplier Cell Signaling Technology Host Rabbit Type Primary Clonality Recombinant (D19A7F3) Recombinant Yes Conjugate Unconjugated Target Forkhead box protein O3 (Human) UniProt O43524 - FOXO3_HUMAN Gene FOXO3 Modification … did chamber come outdid chainsaw man get canceledWebApr 11, 2024 · Nutrition during the developmental stages has long-term effects on adult physiology, disease and lifespan, and is termed nutritional programming. However, the underlying molecular mechanisms of nutritional programming are not yet well understood. In this study, we showed that developmental diets could regulate the lifespan of adult … did chalres g see sins as inevitable in lifeWebJul 25, 2024 · FOXO3a is widely implicated in a variety of diseases, particularly in malignancy of breast, liver, colon, prostate, bladder, and nasopharyngeal cancers. … city life church lansing miWebForkhead box O (FOXO) proteins are a family of transcription factors with four members in mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified as downstream regulators of the insulin pathway, are known to bind to the promoters of a broad variety of target genes and co … Introduction to FOXO Biology city life church charleston