Nephrin antibody
WebSep 26, 2024 · Localization of Nephrin, PDGFR-β and GM3 in glomeruli and the effect of anti-nephrin antibody on the podocyte foot process. ( A ) Immunofluorescence staining images of glomeruli in vehicle mice. WebNephrin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Nephrin. The immunogen is located within the last 50 amino acids of Nephrin. Packaging. 100 μg. Linkage. The action of this antibody can be blocked using blocking peptide SBP2265.
Nephrin antibody
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WebJan 1, 2024 · The threshold for anti-nephrin antibody positivity was set as the maximum titer (187 U/mL) detected in a healthy control population (n = 30). With the use of this standard, only 1 of 54 (2%) of PLA2R+ patients was … WebNephrin (NPHS1, NPHN), also known as is Renal glomerulus-specific cell adhesion receptor, is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive …
http://www.nephjc.com/news/nephrin-mcd WebCells stained with primary antibody (green), and isotype control (orange). 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. Seems to play a role in the development or function of the kidney glomerular filtration barrier.
WebNephrin is a member of the immunoglobulin family of cell adhesion molecules that localizes to opposing sites of the secondary foot processes formed by podocytes, a specialized … WebNephrin is closely associated with the slit diaphragm of the glomerular podocyte, and has recently received attention as a potential therapeutic target. The function of nephrin, ...
WebAntibody: NEPHRIN. Catalog number: GP-N2. Summary: Guinea pig polyclonal IgG against mouse myeloma cell line NS0-derived recombinant human Kirrel3/NEPH2 Tyr33-Ala535. Reacts with human and mouse. Suitable for western blot and immunohistochemistry (frozen and paraffin). For the latter, antigen-retrieval is recommended.
WebResearch Information. nephrin Antibody (G-8) is an IgG 2a κ mouse monoclonal nephrin antibody (also designated NPHS1 antibody, or adhesion molecule nephrin antibody)suitable for the detection of the nephrin protein of mouse, rat and human origin by WB, IP, IF and ELISA. nephrin Antibody (G-8) is available as both the non-conjugated … 口コミ まとめサイトWebAnti-NPHS1 nephrin antibodies are readily available from several suppliers. NPHS1 nephrin is a reported synonym of the human protein 'NPHS1 adhesion molecule, nephrin', encoded by the gene NPHS1. The full protein is reported to be 1241 amino acid residues in length. It is listed to be a member of the Immunoglobulin superfamily. bgm フリー 4分WebThis case strengthens evidence that anti-nephrin antibodies cause disruption of the slit pore diaphragm which appears to be readily responsive to immune therapy. Anti-nephrin mediated podocytopathy may present with a spectrum of glomerular histopathology, which on the background of other susceptibility factors, can lead to more severe presentations … 口コミ マッサージ タイWebThus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3). Application Note. Anti-Nephrin Antibody has been tested for use in ELISA, Western Blotting, immunofluorescence, and immunohistochemistry. Expect a band at approximately 135 kDa in Western Blots of specific cell lysates and tissues. bgm フリー asmrWebThe antibody reacts specifically with nephrin, first described as a kidney podocyte marker protein (MW 135,000 calculated from aa sequence data; apparent Mr 185,000 after SDS-PAGE). Nephrin is a transmembrane cell adhesion molecule located at the slit di… bgm フリー cocWebNov 14, 2024 · Phosphorylation of nephrin can be induced using FKBP-FRB heterodimers. Nephrin is an essential structural component of the kidney glomerulus, a specialized structure for ultrafiltration of plasma, consisting of eight extracellular immunoglobulin G (IgG) repeats, a transmembrane domain, and an unstructured tail of ∼160 amino acids … 口コミ マーケティング 事例WebJul 6, 1999 · We describe here the size and location of nephrin, the first protein to be identified at the glomerular podocyte slit diaphragm. In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in … bgm フリー 40秒