Nephrin
Web中文摘要. Nephrin对保护肾小球滤过屏障具有不可或缺的作用，但其具体功能及机制尚未完全清楚。. 本研究前期建立了doxycycline可逆性调控，RNAi介导的nephrin 基因knockdown小鼠模型。. 首次证明在无其他因素干预下和成年获得性肾病中，nephrin对维持足细胞裂孔膜 … WebAn avid front-runner with a demonstrated history of working in the higher education industry. Skilled in Coaching, Communication, Creativity Skills, People Management, and Presentation Skills. MD from Universitas Gadjah Mada Pelajari lebih lanjut pengalaman kerja, pendidikan, dan koneksi Gerry Nathan Reynaldi, MD serta banyak lagi dengan …
Nephrin
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WebThe nephron is the minute or microscopic structural and functional unit of the kidney.It is composed of a renal corpuscle and a renal tubule.The renal corpuscle consists of a tuft … WebFeb 22, 2024 · Immunofluorescence analysis revealed that Neph1 and Nephrin, major slit diaphragm constituents, were mislocalized and/or lost. mRNA profiling of Exoc5 knockdown podocytes showed that vesicular ...
Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit … See more Nephrin has been shown to interact with: • CASK, • CD2AP, • CDH3 and • CTNND1, • FYN, See more • Podocyte See more • nephrin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Tryggvason K (2002). "Nephrin: role in normal kidney and in disease". Adv. Nephrol. Necker Hosp. 31: 221–34. PMID 11692461 See more WebElectron microscopic examination was carried out on 10 glomeruli from 4 infants with congenital nephrotic syndrome of the Finnish type (CNF) and 5 glomeruli from 1 control. The thickness of the peripheral glomerular basement membrane (GBM) and lamina densa were measured. The width of the GBM was thinner in CNF than in the control but still within …
WebThis result study supports previous research, which stated that nephrin expression was transiently increased in the first 8 weeks of diabetes in the animal experimental model, followed by reduction in long-term studies in line with increase in proteinuria. 20 Thus, AGE-BSA, KLH, or AGE-BSA-KLH immunization may delay the nephrin reduction in DN mice. WebMay 13, 2005 · Nephrin expression was developed with fluorescein isothiocyanate–tyramide (green) and Na + K + ATPase with Cy3-tyramide (red), following whole-mount fluorescent in situ hybridization. A–C: Different views of a stage 33 pronephros. D,E: Raw volumetric data (D) has a threshold filter applied using Amira (E).
WebThe antibody reacts specifically with nephrin, first described as a kidney podocyte marker protein (MW 135,000 calculated from aa sequence data; apparent Mr 185,000 after SDS …
WebOct 15, 2009 · Nephrin increases insulin secretion , and nephrin modulates actin cytoskeleton remodeling (9,13). Therefore, we tested if nephrin trafficking from the … bsvwithuWebUsing immunofluorescence (IF), we found that ephrin-B1 was expressed along the glomerular capillary loop. Immunoelectron microscopy revealed that ephrin-B1 expression was restricted at the slit diaphragm. Dual labeled IF showed ephrin-B1 colocalized with the slit diaphragm proteins nephrin and CD2-associated protein. executive assistant alternate titlesWebAbstract. Urinary podocin and nephrin mRNAs (podocyturia), as candidate biomarkers of endothelial/podocyte injury, were measured by quantitative PCR in Type II diabetics with normal albumin excretion rates (AER) at baseline, at 3–4 years, and at 7 years. Development of cardiovascular disease (CVD) was collected as outcome. bsv worthWebThe PLEKHH2 protein had an apparent molecular mass of 120 kD. Immunofluorescence analysis showed PLEKHH2 in a linear pattern around glomerular capillary loops that partly colocalized with nephrin (NPHS1; 602716), indicating localization to … executive assistant and chief of staffWebNov 23, 2014 · Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part of podocytes, which—together with endothelial cells and the basement—form the glomerular filtration barrier. executive assistant 3 salary gradeWebMar 21, 2024 · Stage 3: The eGFR score is 30 to 59, which may indicate moderate kidney damage. Stage 4: The eGFR score is 15 to 29, indicating severe kidney damage. Stage 5: An eGFR score below 15 means your ... executive assistant advertising agencyWebMar 2, 2024 · The discovery of anti-nephrin antibody “dusting” in these biopsy specimens is accompanied by the presence of high levels of anti-nephrin antibody in the serum. It is … executive assistant alternative job title