SpletIntroduction Diabetic patients may develop acute lung injury less often than non-diabetics; a fact that could be partially ascribed to the usage of antidiabetic drugs, including metformin. Metformin exhibits pleiotropic properties which make it potentially beneficial against lung injury. We hypothesized that pretreatment with metformin preserves alveolar capillary … SpletKeywords: title:the mechanical memory of lung myofibroblasts. All Articles Chapters Sort search results by Search filters. rsc.org; Journals, books & databases; Home; About us; …

The mechanical memory of lung myofibroblasts - [scite report]

Splet01. apr. 2012 · It is established that myofibroblast contraction functions as a mechanism to directly activate TGF-β1 from self-generated stores in the extracellular matrix (ECM), … SpletScale bar = 100 m m. from publication: The mechanical memory of lung myofibroblasts Fibroblasts differentiate into the highly synthetic and contractile myofibroblast phenotype when exposed to ... glycerin fasting

Cell outgrowth on pathophysiologically stiff substrates . Lung ...

SpletHence, mechano-sensed information relating to physical conditions of the local cellular environment could permanently induce fibrotic behavior of lung fibroblasts. This priming … SpletThe molecular determinants of myofibroblast activation in fibrosis and tumor stroma have traditionally been viewed to include biochemical agents, such as dysregulated growth factor and cytokine signaling, which profoundly alter the biology of fibroblasts, ultimately leading to overexuberant matrix deposition and fibrosis. Splet20. feb. 2013 · The importance of mechanical forces to myofibroblast activation and matrix deposition was demonstrated first for skin and mucosal wounds [50–52], and has since been shown for myofibroblasts in multiple tissues including heart , lung [11, 54, 55], liver [56–58], and kidney [59, 60], although different amounts of force may be required in ... bolitho standard